Eh, I separate it into 3 things, historical inaccuracy, scientific inaccuracy and gender-bender.
I have rather large tolerance to historical inaccuracy and tend to consider it "what if scenario" and straight up "alt history". The only times when I have an issue is when authors becomes apologist to IRL historical events NOT how they are in that alternative timeline but how they are in our. So if it's about WWII then stuff like making Nazi SS troops were good guys, claiming that Japanese army behaved honorable during their occupation of Chinese territories or claiming that nuking Hiroshima and Nagasaki is a good decision that saved millions of lives. I repeat, it all can be truth in the story with different circumstances and I will not care about this but it wasn't truth in real world and shouldn't be claimed as one. Because I see it as a grave disrespect to the victims and their descendants. Changing personality is also lands here if somebody even have historically recorded personality instead of just tradition in the other media.
For scientific inaccuracy while I understand that suspension of disbelief is important but the amount I can handle is different and depends on genre. Basically the more the setting differs from the real world the more I can handle, if difference in physical processes is explained by some mineral, radiation, magic, quantum physics breakthrought etc. that wasn't in our world then all is the better. But if no such things in effect and author goes in deep explanation about metallurgy, agriculture, human biology, computer science and binary logic in particular or any other field that is familiar for me where he is wrong then I can close my eyes on one error or two, but should there be more and they are going to be systematic or just very important for the story then my opinion of the story drops very quickly until I drop the story itself. Unexplained differences are easier to accept than wrongly explained ones.
Gender-bender is absolutely not my thing. I consider it as an either strange perverse diviation which is disrespectfull for the historical figures (Nobunaga Oda isn't waifu material! Cao Cao wasn't lesbian loli! ) or rewriting history to push agenda of either feminists or LGTBQ+. Now I can tolerate it if only one character changed their gender, considering it "what if" scenario but I can't even play hentai games where it is systematic. And mind you, overwise I can play very weird hentai games.