Yes.
Kill the main character.
What could go wrong?
It couldn't possibly affect the flow of the overarching story in any meaningful way, could it?
I could image it already.
The heroine in the middle of the love triangle wonders whether to select the ruggedly handsome Richard or handsomely rugged Victor, and then ....
Suddenly, out of the swirling portal of eldritch energies, a mysterious Toyota truck emerges and hits Victor. A blood splashes on the white paint of the truck, the body is thrown, and the Toyota trucks speeds away.
Perhaps our heroine wouldn't be conflicted, but ...
... but even Victor gone, she still couldn't choose ruggedly handsome Richard!
With the squealing wheels, the Toyota truck turns, engine roaring. Richard tries to run, but the Toyota heavy truck was faster....