Well, Urusai Yatsura by Rumiko Takahara is considered the OG Harem Manga/Anime, and it had the MC paired with exactly 2 women. So, that being the case, absolutely yes. It was only Ranma 1/2, the NEXT work after that by the same Manga Ka that solidified it as being multiple sutors, as well as establishing the majority of the modern harem tropes. But, the original had only 2, so it counts.
(Also, highly recommended for any person writing a harem to study and understand Ranma 1/2 and what made it so good, it's still to this day considered the single strongest entry in the entire genre with none of the later imitators even coming close.)