Depends on the quality and aim of criticism.
Most of the criticisms I received here and in Royal Road complained about my MC's apparent 'beta'-ness, which is based on my plans for him to grow as the story progressed (and his personality as well; I risked giving him one to avoid generic isekai MCs). Or some reader who's pushing me to change the word I've written to what he thinks is better (though I really intended it to be like that). Or some reader who kept on complaining, "Where's the seggs?" (Realizing how most readers of SH love smut, I came to an understanding that I won't receive a good feedback here.) So, I threw all those criticisms away as 'worthless'.
I received negative criticisms on other sites too, but those are for improving the work, since the reader invested a lot in my stories. Those are the criticisms I take seriously.
Edit: I also encountered a nitpicker on WebNovel (from Jamaica), which I really took time to answer each and every of his concerns. In the end, he realized he's making an idiot of himself, and he quietly withdrew.